At least 42 distinct members of the family have been discovered
in C. elegans, 11 in Drosophila and 1 in yeast. The
human genome project has identified 14 2P K channel sequences of which
12 have been expressed heterologously and 2 are presently non-functional.
The Yost lab has cloned and studied three of these clones, indicated by the in the following pages.
The proposed membrane topology of a tandem pore potassium channel.